Heparin enhances protamine disulfide bond reduction during in vitro decondensation of human spermatozoa | Zendy

Vanina Laura Julianelli | Zendy; B. Farrando | Zendy; C. Alvarez Sedó | Zendy; Lucrecia Calvo | Zendy; Marina Romanato | Zendy; Juan Carlos Calvo | Zendy

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Heparin enhances protamine disulfide bond reduction during in vitro decondensation of human spermatozoa

Author(s) -

Vanina Laura Julianelli,

B. Farrando,

C. Alvarez Sedó,

Lucrecia Calvo,

Marina Romanato,

Juan Carlos Calvo

Publication year - 2012

Publication title -

human reproduction

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 2.446

H-Index - 226

eISSN - 1460-2350

pISSN - 0268-1161

DOI - 10.1093/humrep/des139

Subject(s) - protamine , sperm , dithiothreitol , glutathione , chemistry , acridine orange , biochemistry , microbiology and biotechnology , biology , heparin , apoptosis , botany , enzyme

Human sperm nuclear decondensation in vivo involves protamine disulfide bond reduction by glutathione (GSH) and protamine/histone exchange, presumably with heparan sulfate (HS) as the protamine acceptor. The aim of the present study was to test the hypothesis that these two events occur simultaneously rather than sequentially, as has been hitherto accepted, and to test for the presence of HS in the human oocyte.

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