Expression of leukaemia inhibitory factor and interleukin 15 in endometrium of women with recurrent implantation failure after IVF; correlation with the number of endometrial natural killer cells | Zendy

Najat Mariee | Zendy; Tin Chiu Li | Zendy; Susan Laird | Zendy

Open Access

Expression of leukaemia inhibitory factor and interleukin 15 in endometrium of women with recurrent implantation failure after IVF; correlation with the number of endometrial natural killer cells

Author(s) -

Najat Mariee,

Tin Chiu Li,

Susan Laird

Publication year - 2012

Publication title -

human reproduction

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 2.446

H-Index - 226

eISSN - 1460-2350

pISSN - 0268-1161

DOI - 10.1093/humrep/des134

Subject(s) - endometrium , leukemia inhibitory factor , embryo , natural killer cell , implantation failure , biology , interleukin , interleukin 2 , andrology , endocrinology , medicine , immunology , cancer research , interleukin 6 , pregnancy , cytokine , cytotoxic t cell , in vitro , infertility , microbiology and biotechnology , biochemistry , genetics

Several studies have suggested that endometrial interleukin 15 (IL-15) and the leukaemia inhibitory factor (LIF) may be important in embryo implantation. IL-15 is postulated to play a role in the control of uterine natural killer (uNK) cell proliferation and function, and uNK cells are also known to play a role in implantation. The aims of this study was to (1) compare endometrial levels of IL-15 and the LIF in women with recurrent implantation failure (RIF) after IVF with those in fertile women (controls) and (2) examine the relation of IL-15 and LIF levels to the uNK cell number.

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