The nuclear factor- B pathway is involved in matrix metalloproteinase-9 expression in RU486-induced endometrium breakdown in mice | Zendy

Yunsong Li | Zendy; Xiaojuan Xu | Zendy; Xudong Chen | Zendy; Wei Guo | Zendy; Bin He | Zendy; J.-D. Wang | Zendy

Open Access

The nuclear factor- B pathway is involved in matrix metalloproteinase-9 expression in RU486-induced endometrium breakdown in mice

Author(s) -

Yunsong Li,

Xiaojuan Xu,

Xudong Chen,

Wei Guo,

Bin He,

J.-D. Wang

Publication year - 2012

Publication title -

human reproduction

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 2.446

H-Index - 226

eISSN - 1460-2350

pISSN - 0268-1161

DOI - 10.1093/humrep/des110

Subject(s) - stromal cell , biology , pyrrolidine dithiocarbamate , mmp9 , western blot , microbiology and biotechnology , decidual cells , chromatin immunoprecipitation , nf κb , signal transduction , endocrinology , chemistry , gene expression , cancer research , placenta , downregulation and upregulation , promoter , fetus , biochemistry , pregnancy , genetics , gene

Progesterone-withdrawal (WP)-induced endometrial breakdown occurs in both physiological and pathological processes such as menstruation and abortion. However, the underlying mechanisms are not clearly understood. As the nuclear factor-κB (NF-κB) pathway has been proposed to play a role in endometrial breakdown, we tested this hypothesis using RU486-induced mouse menstruation-like model.

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