Chemerin inhibits IGF-1-induced progesterone and estradiol secretion in human granulosa cells | Zendy

Maxime Reverchon | Zendy; Marion Cornuau | Zendy; Christelle Ramé | Zendy; Fabrice Guérif | Zendy; Dominique Royère | Zendy; Joëlle Dupont | Zendy

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Chemerin inhibits IGF-1-induced progesterone and estradiol secretion in human granulosa cells

Author(s) -

Maxime Reverchon,

Marion Cornuau,

Christelle Ramé,

Fabrice Guérif,

Dominique Royère,

Joëlle Dupont

Publication year - 2012

Publication title -

human reproduction

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 2.446

H-Index - 226

eISSN - 1460-2350

pISSN - 0268-1161

DOI - 10.1093/humrep/des089

Subject(s) - chemerin , endocrinology , medicine , adipokine , aromatase , granulosa cell , follicular fluid , progesterone receptor , biology , receptor , chemistry , follicular phase , estrogen receptor , leptin , microbiology and biotechnology , oocyte , embryo , cancer , breast cancer , obesity

Chemerin is a novel adipokine involved in the regulation of adipocyte development, inflammation and metabolic functions. To date, no role of this adipokine in reproductive functions has been described. In the present study, we identified chemerin and its receptor, CMKLR1 (chemokine-like receptor 1), in primary human granulosa cells (hGCs) and in a human ovarian granulosa-like tumour cell line (KGN). We also investigated the effects of recombinant human chemerin (rhChem) on steroid production and on various signalling pathways.

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