Induction of endometriosis alters the peripheral and endometrial regulatory T cell population in the non-human primate | Zendy

Andrea Braundmeier | Zendy; Kevin S. Jackson | Zendy; Julie M. Hastings | Zendy; J. S. Koehler | Zendy; Romana A. Nowak | Zendy; Asgerally T. Fazleabas | Zendy

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Induction of endometriosis alters the peripheral and endometrial regulatory T cell population in the non-human primate

Author(s) -

Andrea Braundmeier,

Kevin S. Jackson,

Julie M. Hastings,

J. S. Koehler,

Romana A. Nowak,

Asgerally T. Fazleabas

Publication year - 2012

Publication title -

human reproduction

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 2.446

H-Index - 226

eISSN - 1460-2350

pISSN - 0268-1161

DOI - 10.1093/humrep/des083

Subject(s) - endometriosis , population , pelvic pain , primate , peripheral , fertility , medicine , biology , non human primate , immunology , neuroscience , surgery , evolutionary biology , environmental health

Endometriosis is a gynecological condition that is characterized by extreme abdominal pain and also decreased fertility. Regulatory T cells (Tregs) have immunosuppressive activity critical for embryonic implantation and likewise the acceptance of tissue engraftment. Utilizing the induced non-human primate (Papio anubis) model of endometriosis, we hypothesize that endometriosis decreases the peripheral and endomet rial Treg profile, whereas ectopic lesions have increased Treg localization.

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