Sperm gene expression profile is related to pregnancy rate after insemination and is predictive of low fecundity in normozoospermic men | Zendy

Sandra Bonache | Zendy; A. Mata | Zendy; María Dolores Burguete Ramos | Zendy; Lluís Bassas | Zendy; Sara Larriba | Zendy

Open Access

Sperm gene expression profile is related to pregnancy rate after insemination and is predictive of low fecundity in normozoospermic men

Author(s) -

Sandra Bonache,

A. Mata,

María Dolores Burguete Ramos,

Lluís Bassas,

Sara Larriba

Publication year - 2012

Publication title -

human reproduction

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 2.446

H-Index - 226

eISSN - 1460-2350

pISSN - 0268-1161

DOI - 10.1093/humrep/des074

Subject(s) - sperm , semen , semen quality , andrology , biology , artificial insemination , fertility , fecundity , insemination , pregnancy rate , semen analysis , male infertility , pregnancy , infertility , genetics , medicine , population , environmental health

Assessment of male fertility is traditionally based on microscopic evaluation of semen. However, the classical semen parameters do not adequately reflect sperm function, and their clinical value in predicting fertility is limited. We hypothesize that the sperm expression profile could reflect the fertilizing quality of spermatozoa and could be more informative for predicting the in vivo reproductive fitness of men with normal semen parameters.

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