Human testis steroidogenesis is inhibited by phthalates | Zendy

Christèle Lethimonier | Zendy; O Albert | Zendy; Bruno Le Bizec | Zendy; Elisabeth Perdu | Zendy; Daniel Zalko | Zendy; Frédérique Courant | Zendy; Laurianne Lesné | Zendy; F. Guillé | Zendy; Nathalie DejucqRainsford | Zendy; Bernard Jégou | Zendy

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Human testis steroidogenesis is inhibited by phthalates

Author(s) -

Christèle Lethimonier,

O Albert,

Bruno Le Bizec,

Elisabeth Perdu,

Daniel Zalko,

Frédérique Courant,

Laurianne Lesné,

F. Guillé,

Nathalie DejucqRainsford,

Bernard Jégou

Publication year - 2012

Publication title -

human reproduction

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 2.446

H-Index - 226

eISSN - 1460-2350

pISSN - 0268-1161

DOI - 10.1093/humrep/des069

Subject(s) - phthalate , phthalic acid , testosterone (patch) , endocrinology , medicine , leydig cell , chemistry , biology , andrology , hormone , organic chemistry , luteinizing hormone

Phthalic acid esters are widely used in the manufacture of plastics. Numerous studies have shown that these phthalates impair testicular testosterone production in the rat. However, the scarce and contradictory data concerning humans have cast doubt over whether these compounds are also anti-androgenic in man. We therefore investigated the direct effects of di-(2-ethylhexyl) phthalate (DEHP) and mono-(2-ethylhexyl) phthalate (MEHP) on organo-cultured adult human testis and a human cell line.

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