Laeverin/aminopeptidase Q induces trophoblast invasion during human early placentation | Zendy

Akihito Horie | Zendy; Hiroshi Fujiwara | Zendy; Yukiyasu Sato | Zendy; K. Suginami | Zendy; Hisanori Matsumoto | Zendy; M. Maruyama | Zendy; Ikuo Konishi | Zendy; Akira Hattori | Zendy

AI Assistant Blog Pricing

Home ZAIA Blog

Open Access

Laeverin/aminopeptidase Q induces trophoblast invasion during human early placentation

Author(s) -

Akihito Horie,

Hiroshi Fujiwara,

Yukiyasu Sato,

K. Suginami,

Hisanori Matsumoto,

M. Maruyama,

Ikuo Konishi,

Akira Hattori

Publication year - 2012

Publication title -

human reproduction

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 2.446

H-Index - 226

eISSN - 1460-2350

pISSN - 0268-1161

DOI - 10.1093/humrep/des068

Subject(s) - biology , placentation , trophoblast , blot , immunostaining , syncytiotrophoblasts , placenta , western blot , microbiology and biotechnology , glycoprotein , fetal membrane , immunology , fetus , immunohistochemistry , biochemistry , genetics , gene , pregnancy

In primate placenta, extravillous trophoblast (EVT) invades maternal tissue in temporally- and spatially-regulated fashions. We previously identified a novel placenta-specific cell-surface aminopeptidase, laeverin/aminopeptidase Q, which is expressed on EVT-lineage cells in the fetal membrane. Laeverin possesses a peptide-binding site that is evolutionally unique to primates, suggesting possible involvement of laeverin in a primate-specific phenomenon during placentation. Thus, this study was designed to elucidate the molecular characteristics and physiological roles of laeverin in human EVT.

The content you want is available to Zendy users.

Already have an account? Click here to sign in.

Having issues? You can contact us here

Accelerating Research