CD147 regulates apoptosis in mouse spermatocytes but not spermatogonia | Zendy

Hao Chen | Zendy; Kin Lam Fok | Zendy; Xiaohua Jiang | Zendy; JianLi Jiang | Zendy; ZhiNan Chen | Zendy; Yaoting Gui | Zendy; Hsiao Chang Chan | Zendy; Zhiming Cai | Zendy

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CD147 regulates apoptosis in mouse spermatocytes but not spermatogonia

Author(s) -

Hao Chen,

Kin Lam Fok,

Xiaohua Jiang,

JianLi Jiang,

ZhiNan Chen,

Yaoting Gui,

Hsiao Chang Chan,

Zhiming Cai

Publication year - 2012

Publication title -

human reproduction

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 2.446

H-Index - 226

eISSN - 1460-2350

pISSN - 0268-1161

DOI - 10.1093/humrep/des050

Subject(s) - apoptosis , tunel assay , biology , germ cell , spermatogenesis , terminal deoxynucleotidyl transferase , microbiology and biotechnology , andrology , blot , endocrinology , medicine , genetics , gene

Spermatogenesis is maintained by a dynamic balance between germ cell proliferation and apoptosis. Previous study has demonstrated that CD147 knockout mice are infertile with arrested germ cells. However, the question of whether and how CD147 may be involved in the apoptotic process during spermatogenesis remains elusive. The aim of this study was to evaluate the role of CD147 in the regulation of germ cell apoptosis in mice.

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