Delay in oocyte aging in mice by the antioxidant N-acetyl-l-cysteine (NAC) | Zendy

Jinmiao Liu | Zendy; Mengyuan Liu | Zendy; Xiaoying Ye | Zendy; Kai Liu | Zendy; Junjiu Huang | Zendy; Lingling Wang | Zendy; Guangzhen Ji | Zendy; Na Liu | Zendy; Xiangdong Tang | Zendy; Jay M. Baltz | Zendy; David L. Keefe | Zendy; Lin Liu | Zendy

AI Assistant Blog Pricing

Home ZAIA Blog

Open Access

Delay in oocyte aging in mice by the antioxidant N-acetyl-l-cysteine (NAC)

Author(s) -

Jinmiao Liu,

Mengyuan Liu,

Xiaoying Ye,

Kai Liu,

Junjiu Huang,

Lingling Wang,

Guangzhen Ji,

Na Liu,

Xiangdong Tang,

Jay M. Baltz,

David L. Keefe,

Lin Liu

Publication year - 2012

Publication title -

human reproduction

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 2.446

H-Index - 226

eISSN - 1460-2350

pISSN - 0268-1161

DOI - 10.1093/humrep/des019

Subject(s) - oxidative stress , andrology , reactive oxygen species , telomere , senescence , telomerase , biology , oocyte , embryo , acetylcysteine , ageing , dna damage , antioxidant , endocrinology , medicine , microbiology and biotechnology , genetics , biochemistry , dna , gene

Ovarian aging is associated with declining numbers and quality of oocytes and follicles. Oxidative stress by reactive oxygen species (ROS) contributes to somatic aging in general, and also has been implicated in reproductive aging. Telomere shortening is also involved in aging, and telomeres are particularly susceptible to ROS-induced damage. Previously, we have shown that antioxidant N-acetyl-L-cysteine (NAC) effectively rescues oocytes and embryos from ROS-induced telomere shortening and apoptosis in vitro. Using mice as models, we tested the hypothesis that reducing oxidative stress by NAC might prevent or delay ovarian aging in vivo.

The content you want is available to Zendy users.

Already have an account? Click here to sign in.

Having issues? You can contact us here

Accelerating Research