Physiological sex steroid replacement in premature ovarian failure: randomized crossover trial of effect on uterine volume, endometrial thickness and blood flow, compared with a standard regimen | Zendy

R O’Donnell | Zendy; Pamela Warner | Zendy; R. J. Lee | Zendy; Jane Walker | Zendy; Louise Bath | Zendy; C.J.H. Kelnar | Zendy; William H. Wallace | Zendy; Hilary Critchley | Zendy

Open Access

Physiological sex steroid replacement in premature ovarian failure: randomized crossover trial of effect on uterine volume, endometrial thickness and blood flow, compared with a standard regimen

Author(s) -

R O’Donnell,

Pamela Warner,

R. J. Lee,

Jane Walker,

Louise Bath,

C.J.H. Kelnar,

William H. Wallace,

Hilary Critchley

Publication year - 2012

Publication title -

human reproduction

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 2.446

H-Index - 226

eISSN - 1460-2350

pISSN - 0268-1161

DOI - 10.1093/humrep/des004

Subject(s) - uterine artery , medicine , norethisterone , regimen , crossover study , levonorgestrel , ethinylestradiol , gynecology , urology , pregnancy , biology , population , placebo , genetics , gestation , alternative medicine , environmental health , pathology , family planning , research methodology

Premature ovarian failure (POF) is currently managed by non-physiological sex steroid regimens which are inadequate at optimizing uterine characteristics. Previous short-term studies have demonstrated some benefits of a sex steroid replacement (SSR) regimen devised to replicate the physiological cycle. This study aimed to directly compare the effects of longer-term administration of physiological SSR (pSSR) and standard SSR (sSSR) regimens on the uterine volume, blood flow and endometrial thickness (ET) in women with POF.

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