Should androgen supplementation be used for poor ovarian response in IVF? | Zendy

Sesh Kamal Sunkara | Zendy; Arri Coomarasamy | Zendy; Wiebke Arlt | Zendy; Siladitya Bhattacharya | Zendy

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Should androgen supplementation be used for poor ovarian response in IVF?

Author(s) -

Sesh Kamal Sunkara,

Arri Coomarasamy,

Wiebke Arlt,

Siladitya Bhattacharya

Publication year - 2012

Publication title -

human reproduction

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 2.446

H-Index - 226

eISSN - 1460-2350

pISSN - 0268-1161

DOI - 10.1093/humrep/der464

Subject(s) - dehydroepiandrosterone , context (archaeology) , medicine , randomized controlled trial , adjuvant , gynecology , androgen , psychological intervention , biology , hormone , paleontology , psychiatry

Poor ovarian response is reported in 9-24% of IVF cycles. Several interventions have been proposed to improve the outcome, although evidence to support these has been scant. There has been interest in the use of adjuvant androgens in this context and a recent worldwide survey showed that nearly a quarter of IVF clinicians used dehydroepiandrosterone (DHEA) in poor responders. We examine the rationale for the use of adjuvant androgens and suggest that the current clinical uncertainty should be addressed by a randomized controlled trial of DHEA in poor responders.

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