High throughput, cell type-specific analysis of key proteins in human endometrial biopsies of women from fertile and infertile couples | Zendy

Richard E. Leach | Zendy; Philip Jessmon | Zendy; Christos Coutifaris | Zendy; Michael Krüger | Zendy; Evan R. Myers | Zendy; Rouba AliFehmi | Zendy; Sandra Ann Carson | Zendy; Richard S. Legro | Zendy; William D. Schlaff | Zendy; Bruce R. Carr | Zendy; Michael P. Steinkampf | Zendy; Susan G. Silva | Zendy; Phyllis C. Leppert | Zendy; Linda C. Giudice | Zendy; Michael P. Diamond | Zendy; D. Randall Armant | Zendy

Open Access

High throughput, cell type-specific analysis of key proteins in human endometrial biopsies of women from fertile and infertile couples

Author(s) -

Richard E. Leach,

Philip Jessmon,

Christos Coutifaris,

Michael Krüger,

Evan R. Myers,

Rouba AliFehmi,

Sandra Ann Carson,

Richard S. Legro,

William D. Schlaff,

Bruce R. Carr,

Michael P. Steinkampf,

Susan G. Silva,

Phyllis C. Leppert,

Linda C. Giudice,

Michael P. Diamond,

D. Randall Armant

Publication year - 2012

Publication title -

human reproduction

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 2.446

H-Index - 226

eISSN - 1460-2350

pISSN - 0268-1161

DOI - 10.1093/humrep/der436

Subject(s) - endometrial biopsy , infertility , transcriptome , endometrium , biology , menstrual cycle , andrology , unexplained infertility , bioinformatics , physiology , endocrinology , medicine , gene expression , gene , pregnancy , genetics , hormone

Although histological dating of endometrial biopsies provides little help for prediction or diagnosis of infertility, analysis of individual endometrial proteins, proteomic profiling and transcriptome analysis have suggested several biomarkers with altered expression arising from intrinsic abnormalities, inadequate stimulation by or in response to gonadal steroids or altered function due to systemic disorders. The objective of this study was to delineate the developmental dynamics of potentially important proteins in the secretory phase of the menstrual cycle, utilizing a collection of endometrial biopsies from women of fertile (n = 89) and infertile (n = 89) couples.

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