HSFY genes and the P4 palindrome in the AZFb interval of the human Y chromosome are not required for spermatocyte maturation | Zendy

Elsa Kichine | Zendy; Virginie Rozé | Zendy; Julie Di Cristofaro | Zendy; Daniel Taulier | Zendy; A. Navarro | Zendy; Eric Streichemberger | Zendy; Fanny Decarpentrie | Zendy; Catherine MetzlerGuillemain | Zendy; Nicolas Lévy | Zendy; Jacques Chiaroni | Zendy; Véronique PaquisFlucklinger | Zendy; Florence Fellmann | Zendy; Michael Mitchell | Zendy

Open Access

HSFY genes and the P4 palindrome in the AZFb interval of the human Y chromosome are not required for spermatocyte maturation

Author(s) -

Elsa Kichine,

Virginie Rozé,

Julie Di Cristofaro,

Daniel Taulier,

A. Navarro,

Eric Streichemberger,

Fanny Decarpentrie,

Catherine MetzlerGuillemain,

Nicolas Lévy,

Jacques Chiaroni,

Véronique PaquisFlucklinger,

Florence Fellmann,

Michael Mitchell

Publication year - 2011

Publication title -

human reproduction

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 2.446

H-Index - 226

eISSN - 1460-2350

pISSN - 0268-1161

DOI - 10.1093/humrep/der421

Subject(s) - biology , spermatocyte , meiosis , genetics , gene , ploidy , chromosome , spermatogenesis , endocrinology

Recurrent AZFb deletions on the human Y chromosome are associated with an absence of ejaculated spermatozoa consequent to a meiotic maturation arrest that prevents the progression of germ cells to haploid stages. The extreme rarity of partial deletions has hampered the identification of the AZFb genes required for normal meiotic stages. The critical interval, refined by two overlapping deletions associated with full spermatogenesis (AZFc and b1/b3), measures over 4 Mb and contains 13 coding genes: CDY2, XKRY, HSFY1, HSFY2, CYORF15A, CYORF15B, KDM5D, EIF1AY, RPS4Y2 and four copies of RBMY.

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