Aberrant expression of metastasis-inducing proteins in ectopic and matched eutopic endometrium of women with endometriosis: implications for the pathogenesis of endometriosis | Zendy

D Hapangama | Zendy; RS Raju | Zendy; Anthony Valentijn | Zendy; Dong L. Barraclough | Zendy; A. A. M. Hart | Zendy; M. Turner | Zendy; Angela PlattHiggins | Zendy; Roger Barraclough | Zendy; Philip S. Rudland | Zendy

Open Access

Aberrant expression of metastasis-inducing proteins in ectopic and matched eutopic endometrium of women with endometriosis: implications for the pathogenesis of endometriosis

Author(s) -

D Hapangama,

RS Raju,

Anthony Valentijn,

Dong L. Barraclough,

A. A. M. Hart,

M. Turner,

Angela PlattHiggins,

Roger Barraclough,

Philip S. Rudland

Publication year - 2011

Publication title -

human reproduction

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 2.446

H-Index - 226

eISSN - 1460-2350

pISSN - 0268-1161

DOI - 10.1093/humrep/der412

Subject(s) - endometriosis , pathogenesis , osteopontin , carcinogenesis , metastasis , cancer research , medicine , endometrium , biology , pathology , cancer , oncology

Endometriosis is a metastatic disease without obvious tumorigenesis. Expression of S100P, S100A4, osteopontin (OPN) or anterior gradient homologue 2 (AGR2) proteins can induce metastasis but fail to induce tumorigenesis per se. We now explore whether this group of metastasis-inducing proteins (MIPs) are associated with the pathogenesis of endometriosis.

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