Long-term outcome in couples with unexplained subfertility and an intermediate prognosis initially randomized between expectant management and immediate treatment | Zendy

I Custers | Zendy; M.M.E. van Rumste | Zendy; Jan Willem van der Steeg | Zendy; Madelon van Wely | Zendy; Peter G.A. Hompes | Zendy; Patrick M. Bossuyt | Zendy; F. J. Broekmans | Zendy; C N M Renckens | Zendy; M. J. C. Eijkemans | Zendy; Thierry J.H.M. van Dessel | Zendy; Fulco van der Veen | Zendy; Ben W. Mol | Zendy; Pieternel Steures | Zendy

Open Access

Long-term outcome in couples with unexplained subfertility and an intermediate prognosis initially randomized between expectant management and immediate treatment

Author(s) -

I Custers,

M.M.E. van Rumste,

Jan Willem van der Steeg,

Madelon van Wely,

Peter G.A. Hompes,

Patrick M. Bossuyt,

F. J. Broekmans,

C N M Renckens,

M. J. C. Eijkemans,

Thierry J.H.M. van Dessel,

Fulco van der Veen,

Ben W. Mol,

Pieternel Steures

Publication year - 2011

Publication title -

human reproduction

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 2.446

H-Index - 226

eISSN - 1460-2350

pISSN - 0268-1161

DOI - 10.1093/humrep/der389

Subject(s) - medicine , pregnancy , gynecology , obstetrics , randomized controlled trial , confidence interval , fertility , pregnancy rate , live birth , randomization , artificial insemination , population , genetics , environmental health , biology

We recently reported that treatment with intrauterine insemination and controlled ovarian stimulation (IUI-COS) did not increase ongoing pregnancy rates compared with expectant management (EM) in couples with unexplained subfertility and intermediate prognosis of natural conception. Long-term cost-effectiveness of a policy of initial EM is unknown. We investigated whether the recommendation not to treat during the first 6 months is valid, regarding the long-term effectiveness and cumulative costs.

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