Possible improvements in human ovarian grafting by various host and graft treatments | Zendy

Or Friedman | Zendy; Raoul Orvieto | Zendy; Benjamin Fisch | Zendy; Carmela Felz | Zendy; Enrique Freud | Zendy; Avi BenHaroush | Zendy; Ronit Abir | Zendy

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Possible improvements in human ovarian grafting by various host and graft treatments

Author(s) -

Or Friedman,

Raoul Orvieto,

Benjamin Fisch,

Carmela Felz,

Enrique Freud,

Avi BenHaroush,

Ronit Abir

Publication year - 2011

Publication title -

human reproduction

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 2.446

H-Index - 226

eISSN - 1460-2350

pISSN - 0268-1161

DOI - 10.1093/humrep/der385

Subject(s) - ovarian tissue cryopreservation , cryopreservation , ovarian tissue , transplantation , medicine , fertility preservation , follicular phase , ovarian follicle , revascularization , surgery , andrology , fertility , biology , ovary , embryo , population , environmental health , microbiology and biotechnology , myocardial infarction

Anticancer treatment poses a high risk of ovarian failure. In many cases cryopreservation of ovarian tissue is the only option for fertility preservation. Although autologous transplantation of cryopreserved-thawed ovarian tissue has resulted in live births, slow graft revascularization and ischemia after transplantation leads to substantial follicular loss. Therefore, methods to improve and hasten graft vascularization are needed. The aim of the study was to examine the benefits of host and graft treatments with melatonin, hyaluronan (HA), vascular endothelial growth factor A (VEGF-A) and vitamin E with regard to the outcome of human ovarian tissue grafting.

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