Non-invasive metabolomic profiling of Day 2 and 5 embryo culture medium: a prospective randomized trial | Zendy

Thorir Hardarson | Zendy; Aisling Ahlström | Zendy; L. Rogberg | Zendy; L. Botros | Zendy; Torbjörn Hillensjø | Zendy; Göran Westlander | Zendy; Denny Sakkas | Zendy; Matts Wikland | Zendy

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Non-invasive metabolomic profiling of Day 2 and 5 embryo culture medium: a prospective randomized trial

Author(s) -

Thorir Hardarson,

Aisling Ahlström,

L. Rogberg,

L. Botros,

Torbjörn Hillensjø,

Göran Westlander,

Denny Sakkas,

Matts Wikland

Publication year - 2011

Publication title -

human reproduction

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 2.446

H-Index - 226

eISSN - 1460-2350

pISSN - 0268-1161

DOI - 10.1093/humrep/der373

Subject(s) - randomized controlled trial , embryo culture , medicine , metabolomics , profiling (computer programming) , gynecology , andrology , embryo , biology , bioinformatics , embryogenesis , computer science , genetics , operating system

Near infrared (NIR) spectroscopy is a technology proposed to facilitate non-invasive screening for the most optimal human embryo for uterine transfer. It has been proposed that the NIR spectral profile of an embryo's spent culture medium can be used to generate a viability score that correlates to implantation potential. As the initial proof of principle studies were all retrospective, our aim was to investigate whether NIR spectroscopy on spent embryo culture medium in an on-site, prospective setting could improve the ongoing single embryo transfer (SET) pregnancy rate after Day 2 and 5 transfers.

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