MIC-1 (a multifunctional modulator of dendritic cell phenotype and function) is produced by decidual stromal cells and trophoblasts | Zendy

Stephan Segerer | Zendy; Lorenz Rieger | Zendy; M Kapp | Zendy; Yvonne Dombrowski | Zendy; Nora Müller | Zendy; J. Dietl | Zendy; Ulrike Kämmerer | Zendy

Open Access

MIC-1 (a multifunctional modulator of dendritic cell phenotype and function) is produced by decidual stromal cells and trophoblasts

Author(s) -

Stephan Segerer,

Lorenz Rieger,

M Kapp,

Yvonne Dombrowski,

Nora Müller,

J. Dietl,

Ulrike Kämmerer

Publication year - 2011

Publication title -

human reproduction

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 2.446

H-Index - 226

eISSN - 1460-2350

pISSN - 0268-1161

DOI - 10.1093/humrep/der358

Subject(s) - trophoblast , cytokine , stromal cell , microbiology and biotechnology , decidua , decidual cells , biology , macrophage , immunology , inflammation , placenta , pregnancy , cancer research , in vitro , fetus , biochemistry , genetics

Macrophage inhibitory cytokine-1 (MIC-1) is a multifunctional cytokine produced in high amounts by placental tissue. Inhibiting trophoblast invasion and suppressing inflammation through inhibition of macrophage activation, MIC-1 is thought to provide pleiotropic functions in the establishment and maintenance of pregnancy. So far, little is known about the decidual cell subsets producing MIC-1 and the effect of this cytokine on dendritic cells (DCs), which are known to play a distinct role in the development of pro-fetal tolerance in pregnancy.

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