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Insulin-induced capillary recruitment is impaired in both lean and obese women with PCOS
Author(s) -
I.J.G. Ketel,
Erik H. Serné,
Richard G. IJzerman,
T. Korsen,
Jos W. R. Twisk,
Peter G.A. Hompes,
Yvo M. Smulders,
Roy Homburg,
L. Vorstermans,
Coen D.A. Stehouwer,
Cornelis B. Lambalk
Publication year - 2011
Publication title -
human reproduction
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 2.446
H-Index - 226
eISSN - 1460-2350
pISSN - 0268-1161
DOI - 10.1093/humrep/der296
Subject(s) - hyperinsulinemia , medicine , endocrinology , polycystic ovary , insulin resistance , insulin , obesity , glucose clamp technique , diabetes mellitus , pancreatic hormone
Insulin resistance, i.e. impaired insulin-mediated glucose uptake (IMGU), is a major risk factor for type 2 diabetes in women with polycystic ovary syndrome (PCOS). Insulin-induced capillary recruitment (IICR) is considered a significant determinant of IMGU. We investigated whether IICR is a determinant IMGU in obese and lean women with and without PCOS.

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