Insulin-induced capillary recruitment is impaired in both lean and obese women with PCOS
Author(s) -
I.J.G. Ketel,
Erik H. Serné,
Richard G. IJzerman,
T. Korsen,
Jos W. R. Twisk,
Peter G.A. Hompes,
Yvo M. Smulders,
Roy Homburg,
L. Vorstermans,
Coen D.A. Stehouwer,
Cornelis B. Lambalk
Publication year - 2011
Publication title -
human reproduction
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 2.446
H-Index - 226
eISSN - 1460-2350
pISSN - 0268-1161
DOI - 10.1093/humrep/der296
Subject(s) - hyperinsulinemia , medicine , endocrinology , polycystic ovary , insulin resistance , insulin , obesity , glucose clamp technique , diabetes mellitus , pancreatic hormone
Insulin resistance, i.e. impaired insulin-mediated glucose uptake (IMGU), is a major risk factor for type 2 diabetes in women with polycystic ovary syndrome (PCOS). Insulin-induced capillary recruitment (IICR) is considered a significant determinant of IMGU. We investigated whether IICR is a determinant IMGU in obese and lean women with and without PCOS.
Accelerating Research
Robert Robinson Avenue,
Oxford Science Park, Oxford
OX4 4GP, United Kingdom
Address
John Eccles HouseRobert Robinson Avenue,
Oxford Science Park, Oxford
OX4 4GP, United Kingdom