Interleukin (IL)11 mediates protein secretion and modification in human extravillous trophoblasts | Zendy

Stefan Sonderegger | Zendy; Joanne Yap | Zendy; Ellen Menkhorst | Zendy; Gareth Weston | Zendy; Peter G. Stanton | Zendy; Evdokia Dimitriadis | Zendy

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Interleukin (IL)11 mediates protein secretion and modification in human extravillous trophoblasts

Author(s) -

Stefan Sonderegger,

Joanne Yap,

Ellen Menkhorst,

Gareth Weston,

Peter G. Stanton,

Evdokia Dimitriadis

Publication year - 2011

Publication title -

human reproduction

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 2.446

H-Index - 226

eISSN - 1460-2350

pISSN - 0268-1161

DOI - 10.1093/humrep/der259

Subject(s) - trophoblast , western blot , microbiology and biotechnology , biology , secretion , endoplasmic reticulum , placenta , decidua , signal transduction , secretory protein , secretory pathway , immunology , endocrinology , biochemistry , golgi apparatus , gene , pregnancy , genetics , fetus

Human trophoblast invasion and differentiation are essential for a successful pregnancy outcome. Dysregulation of these processes can lead to placental pathologies such as pre-eclampsia. The molecular mechanisms; however, are poorly understood. Interleukin (IL)11--a cytokine that regulates endometrial epithelial cell adhesion, trophoblast motility and invasion during implantation--may be involved in some of these processes.

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