Improvements in human sperm quality by long-term in vitro co-culture with isolated porcine Sertoli cells | Zendy

Massimo Menegazzo | Zendy; Daniela Zuccarello | Zendy; Giovanni Luca | Zendy; Alberto Ferlin | Zendy; Mario Calvitti | Zendy; Francesca Mancuso | Zendy; R. Calafiore | Zendy; Carlo Foresta | Zendy

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Improvements in human sperm quality by long-term in vitro co-culture with isolated porcine Sertoli cells

Author(s) -

Massimo Menegazzo,

Daniela Zuccarello,

Giovanni Luca,

Alberto Ferlin,

Mario Calvitti,

Francesca Mancuso,

R. Calafiore,

Carlo Foresta

Publication year - 2011

Publication title -

human reproduction

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 2.446

H-Index - 226

eISSN - 1460-2350

pISSN - 0268-1161

DOI - 10.1093/humrep/der248

Subject(s) - sperm , hyperactivation , capacitation , andrology , biology , acrosome reaction , spermatogenesis , sperm motility , sertoli cell , motility , dna fragmentation , human fertilization , microbiology and biotechnology , endocrinology , anatomy , apoptosis , programmed cell death , medicine , genetics

Spermatogenesis is a complex process where spermatogonial germ cells become spermatozoa with the indispensable support of Sertoli cells (SCs), which provide 'ad hoc' structural and nutritional support. Unfortunately, for most sperm dysfunctions, no therapies are yet available except assisted reproductive technologies (ART) that are based on the use of different culture media to preserve sperm in vitro. However, sperm culture is only possible for short periods of time, since long-term culture would invariably and irreversibly damage the cells with negative impact on their fertilization potential.

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