Toll-like receptors (TLR) 2 and 4 on human sperm recognize bacterial endotoxins and mediate apoptosis | Zendy

Yoko Fujita | Zendy; Toshiyuki Mihara | Zendy; T. Okazaki | Zendy; Manami Shitanaka | Zendy; R. Kushino | Zendy; Chiaki Ikeda | Zendy; Hideyuki Negishi | Zendy; Zhenying Liu | Zendy; JoAnne S. Richards | Zendy; Masayuki Shimada | Zendy

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Toll-like receptors (TLR) 2 and 4 on human sperm recognize bacterial endotoxins and mediate apoptosis

Author(s) -

Yoko Fujita,

Toshiyuki Mihara,

T. Okazaki,

Manami Shitanaka,

R. Kushino,

Chiaki Ikeda,

Hideyuki Negishi,

Zhenying Liu,

JoAnne S. Richards,

Masayuki Shimada

Publication year - 2011

Publication title -

human reproduction

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 2.446

H-Index - 226

eISSN - 1460-2350

pISSN - 0268-1161

DOI - 10.1093/humrep/der234

Subject(s) - tumor necrosis factor alpha , biology , immunology , receptor , sperm motility , lipopolysaccharide , infertility , toll like receptor , secretion , innate immune system , motility , semen , microbiology and biotechnology , sperm , tlr4 , immune system , endocrinology , genetics , pregnancy

Bacterial infections of the genital tract are one of the most serious causes of infertility in males. In some human patients with poor semen quality, leukocytospermia has been observed. Because leukocytes express the bacterial-lipopolysaccharide (LPS) responsive Toll-like receptor (TLR) signaling cascade and secrete tumor necrosis factor-α, secreted cytokines comprise one, but probably not the only, class of factors that can impact sperm motility.

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