Interaction between uterine natural killer cells and extravillous trophoblast cells: effect on cytokine and angiogenic growth factor production | Zendy

Gendie E. Lash | Zendy; Katsuhiko Naruse | Zendy; Andrew Robson | Zendy; Barbara A. Innes | Zendy; R.F. Searle | Zendy; Stephen C. Robson | Zendy; Judith N. Bulmer | Zendy

Open Access

Interaction between uterine natural killer cells and extravillous trophoblast cells: effect on cytokine and angiogenic growth factor production

Author(s) -

Gendie E. Lash,

Katsuhiko Naruse,

Andrew Robson,

Barbara A. Innes,

R.F. Searle,

Stephen C. Robson,

Judith N. Bulmer

Publication year - 2011

Publication title -

human reproduction

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 2.446

H-Index - 226

eISSN - 1460-2350

pISSN - 0268-1161

DOI - 10.1093/humrep/der198

Subject(s) - cytokine , trophoblast , immunology , biology , microbiology and biotechnology , pregnancy , placenta , fetus , genetics

Uterine natural killer (uNK) cells are a major source of cytokines and angiogenic growth factors (AGFs), with AGF levels decreasing and cytokine levels increasing with gestational age. The factors that regulate AGF and cytokine secretion are unclear but may involve interactions between uNK cells and extravillous trophoblast (EVT) cells. We hypothesize that uNK cell interaction with EVT cells alters their cytokine and AGF secretion.

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