The antibody-mediated targeted delivery of interleukin-10 inhibits endometriosis in a syngeneic mouse model | Zendy

Kathrin Schwager | Zendy; Frank Bootz | Zendy; Patrick Imesch | Zendy; Manuela Kaspar | Zendy; Eveline Trachsel | Zendy; Dario Neri | Zendy

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The antibody-mediated targeted delivery of interleukin-10 inhibits endometriosis in a syngeneic mouse model

Author(s) -

Kathrin Schwager,

Frank Bootz,

Patrick Imesch,

Manuela Kaspar,

Eveline Trachsel,

Dario Neri

Publication year - 2011

Publication title -

human reproduction

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 2.446

H-Index - 226

eISSN - 1460-2350

pISSN - 0268-1161

DOI - 10.1093/humrep/der195

Subject(s) - endometriosis , antibody , medicine , immunohistochemistry , immunofluorescence , cytokine , antigen , pathology , immunology

Endometriosis is still a highly underdiagnosed disease, and the current medical and surgical treatment of endometriosis is associated with a high recurrence rate. This study investigates the use of derivatives of the human antibody F8, specific to the alternatively spliced extra-domain A of fibronectin (Fn), for the imaging and treatment of endometriosis.

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