Genome-wide analysis identifies changes in histone retention and epigenetic modifications at developmental and imprinted gene loci in the sperm of infertile men | Zendy

Saher Sue Hammoud | Zendy; David A. Nix | Zendy; Ahmad Hammoud | Zendy; Mark Gibson | Zendy; Bradley R. Cairns | Zendy; Douglas T. Carrell | Zendy

Open Access

Genome-wide analysis identifies changes in histone retention and epigenetic modifications at developmental and imprinted gene loci in the sperm of infertile men

Author(s) -

Saher Sue Hammoud,

David A. Nix,

Ahmad Hammoud,

Mark Gibson,

Bradley R. Cairns,

Douglas T. Carrell

Publication year - 2011

Publication title -

human reproduction

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 2.446

H-Index - 226

eISSN - 1460-2350

pISSN - 0268-1161

DOI - 10.1093/humrep/der192

Subject(s) - genomic imprinting , epigenetics , biology , genetics , sperm , gene , histone , genome , dna methylation , gene expression

The sperm chromatin of fertile men retains a small number of nucleosomes that are enriched at developmental gene promoters and imprinted gene loci. This unique chromatin packaging at certain gene promoters provides these genomic loci the ability to convey instructive epigenetic information to the zygote, potentially expanding the role and significance of the sperm epigenome in embryogenesis. We hypothesize that changes in chromatin packaging may be associated with poor reproductive outcome.

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