The competence of germinal vesicle oocytes is unrelated to nuclear chromatin configuration and strictly depends on cytoplasmic quantity and quality in the cat model | Zendy

Pierre Comizzoli | Zendy; Budhan S. Pukazhenthi | Zendy; D. E. Wildt | Zendy

Open Access

The competence of germinal vesicle oocytes is unrelated to nuclear chromatin configuration and strictly depends on cytoplasmic quantity and quality in the cat model

Author(s) -

Pierre Comizzoli,

Budhan S. Pukazhenthi,

D. E. Wildt

Publication year - 2011

Publication title -

human reproduction

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 2.446

H-Index - 226

eISSN - 1460-2350

pISSN - 0268-1161

DOI - 10.1093/humrep/der176

Subject(s) - germinal vesicle , chromatin , biology , competence (human resources) , cytoplasm , andrology , oocyte , microbiology and biotechnology , genetics , embryo , psychology , medicine , gene , social psychology

Chromatin configuration of the germinal vesicle (GV) and quality of the cytoplasm are critical factors in achieving oocyte meiotic and developmental capacity during folliculogenesis. Besides gaining new insights into the timing and cellular mechanisms associated with the acquisition and regulation of GV oocyte competence, the domestic cat model was used to examine (i) the relation between GV chromatin configuration and oocyte functionality during folliculogenesis and (ii) the role of the cytoplasmic environment on the GV competence and stability.

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