Increased frequency of occult fragile X-associated primary ovarian insufficiency in infertile women with evidence of impaired ovarian function | Zendy

C. B. Karimov | Zendy; Vasiliki A. Moragianni | Zendy; Amy Cronister | Zendy; Serene S. Srouji | Zendy; John C. Petrozza | Zendy; Catherine Racowsky | Zendy; Elizabeth S. Ginsburg | Zendy; Kim L. Thornton | Zendy; Corrine K. Welt | Zendy

Open Access

Increased frequency of occult fragile X-associated primary ovarian insufficiency in infertile women with evidence of impaired ovarian function

Author(s) -

C. B. Karimov,

Vasiliki A. Moragianni,

Amy Cronister,

Serene S. Srouji,

John C. Petrozza,

Catherine Racowsky,

Elizabeth S. Ginsburg,

Kim L. Thornton,

Corrine K. Welt

Publication year - 2011

Publication title -

human reproduction

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 2.446

H-Index - 226

eISSN - 1460-2350

pISSN - 0268-1161

DOI - 10.1093/humrep/der168

Subject(s) - occult , medicine , infertility , fmr1 , fragile x syndrome , premature ovarian insufficiency , allele , asymptomatic , premature ovarian failure , gynecology , genetics , pregnancy , biology , pathology , psychiatry , alternative medicine , gene

The FMR1 premutation is associated with overt primary ovarian insufficiency (POI). However, its prevalence in women with occult POI (i.e. menstrual cycles, but impaired ovarian response) has not been examined. We hypothesized that both the FMR1 premutation and intermediate allele is more frequent in infertile women with occult POI than in controls, and that a repeat length cutoff might predict occult POI.

The content you want is available to Zendy users.

Already have an account? Click here to sign in.

Having issues? You can contact us here

Accelerating Research