Effects of polybrominated diphenyl ethers on steroidogenesis in rat Leydig cells | Zendy

Kai-Lee Wang | Zendy; ShihMin Hsia | Zendy; IFang Mao | Zendy; Mei-Lien Chen | Zendy; Shyi-Wu Wang | Zendy; Paulus S. Wang | Zendy

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Effects of polybrominated diphenyl ethers on steroidogenesis in rat Leydig cells

Author(s) -

Kai-Lee Wang,

ShihMin Hsia,

IFang Mao,

Mei-Lien Chen,

Shyi-Wu Wang,

Paulus S. Wang

Publication year - 2011

Publication title -

human reproduction

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 2.446

H-Index - 226

eISSN - 1460-2350

pISSN - 0268-1161

DOI - 10.1093/humrep/der165

Subject(s) - polybrominated diphenyl ethers , endocrinology , diphenyl ether , leydig cell , medicine , chemistry , polybrominated biphenyls , luteinizing hormone , organic chemistry , pollutant , hormone

Polybrominated diphenyl ethers (PBDEs) are brominated flame retardants that have been defined as major environmental pollutants. While previous studies have found that PBDEs may enhance the levels of sex-steroid hormones, their effects on testosterone secretion from rat Leydig cells are unclear. This study investigated the effects and mechanisms of PBDE-710, a mixture of tetra- and penta-PBDEs, on testosterone biosynthesis in rat Leydig cells.

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