Establishment and characterization of a spontaneously immortalized trophoblast cell line (HPT-8) and its hepatitis B virus-expressing clone | Zendy

Lei Zhang | Zendy; Weilu Zhang | Zendy; Chen Shao | Zendy; Jingxia Zhang | Zendy; Ke Men | Zendy; Zhongjun Shao | Zendy; Yongping Yan | Zendy; DeZhong Xu | Zendy

Open Access

Establishment and characterization of a spontaneously immortalized trophoblast cell line (HPT-8) and its hepatitis B virus-expressing clone

Author(s) -

Lei Zhang,

Weilu Zhang,

Chen Shao,

Jingxia Zhang,

Ke Men,

Zhongjun Shao,

Yongping Yan,

DeZhong Xu

Publication year - 2011

Publication title -

human reproduction

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 2.446

H-Index - 226

eISSN - 1460-2350

pISSN - 0268-1161

DOI - 10.1093/humrep/der153

Subject(s) - trophoblast , biology , cytotrophoblast , microbiology and biotechnology , clone (java method) , cell culture , hepatitis b virus , immortalised cell line , stromal cell , virology , virus , placenta , cancer research , fetus , pregnancy , dna , genetics

Most trophoblast cell lines currently available to study vertical transmission of hepatitis B virus (HBV) are immortalized by viral transformation. Our goal was to establish and characterize a spontaneously immortalized human first-trimester trophoblast cell line and its HBV-expressing clone.

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