MicroRNA-155 is involved in the remodelling of human-trophoblast-derived HTR-8/SVneo cells induced by lipopolysaccharides | Zendy

Yi­min Dai | Zendy; Zongli Diao | Zendy; Haixiang Sun | Zendy; Rong Li | Zendy; Zhihua Qiu | Zendy; Yali Hu | Zendy

Open Access

MicroRNA-155 is involved in the remodelling of human-trophoblast-derived HTR-8/SVneo cells induced by lipopolysaccharides

Author(s) -

Yimin Dai,

Zongli Diao,

Haixiang Sun,

Rong Li,

Zhihua Qiu,

Yali Hu

Publication year - 2011

Publication title -

human reproduction

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 2.446

H-Index - 226

eISSN - 1460-2350

pISSN - 0268-1161

DOI - 10.1093/humrep/der118

Subject(s) - trophoblast , microrna , microbiology and biotechnology , downregulation and upregulation , biology , cell culture , cancer research , placenta , andrology , chemistry , medicine , pregnancy , gene , biochemistry , genetics , fetus

A low dose injection of lipopolysaccharides (LPS) may induce pre-eclampsia-like symptoms in rats, and microRNA-155 (miR-155) is elevated in the placentas of patients with pre-eclampsia. Our goal was to investigate the association of miR-155 with pre-eclampsia and the pathways involved using human-trophoblast-derived cell line (HTR-8/SVneo) stimulated with LPS.

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