A role for Aurora C in the chromosomal passenger complex during human preimplantation embryo development | Zendy

Margarida Avo Santos | Zendy; C. van de Werken | Zendy; Marieke de Vries | Zendy; Holger Jahr | Zendy; Martijn J.M. Vromans | Zendy; Joop S.E. Laven | Zendy; Bart C.J.M. Fauser | Zendy; Geert J.P.L. Kops | Zendy; Susanne M.A. Lens | Zendy; Esther B. Baart | Zendy

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A role for Aurora C in the chromosomal passenger complex during human preimplantation embryo development

Author(s) -

Margarida Avo Santos,

C. van de Werken,

Marieke de Vries,

Holger Jahr,

Martijn J.M. Vromans,

Joop S.E. Laven,

Bart C.J.M. Fauser,

Geert J.P.L. Kops,

Susanne M.A. Lens,

Esther B. Baart

Publication year - 2011

Publication title -

human reproduction

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 2.446

H-Index - 226

eISSN - 1460-2350

pISSN - 0268-1161

DOI - 10.1093/humrep/der111

Subject(s) - prometaphase , aurora b kinase , biology , blastocyst , microbiology and biotechnology , zygote , embryo , mitosis , kinetochore , embryonic stem cell , genetics , chromosome , embryogenesis , gene

Human embryos generated by IVF demonstrate a high incidence of chromosomal segregation errors during the cleavage divisions. To analyse underlying molecular mechanisms, we investigated the behaviour of the chromosomal passenger complex (CPC) in human oocytes and embryos. This important mitotic regulatory complex comprises the inner centromere protein (INCENP), survivin, borealin and Aurora B, or the meiotic kinase Aurora C.

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