PGD for reciprocal and Robertsonian translocations using array comparative genomic hybridization | Zendy

Francesco Fiorentino | Zendy; L. Spizzichino | Zendy; Sara Bono | Zendy; Anıl Biricik | Zendy; Georgia Kokkali | Zendy; Laura Rienzi | Zendy; Filippo Maria Ubaldi | Zendy; E. Iammarrone | Zendy; Adam Gordon | Zendy; K. Pantos | Zendy

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PGD for reciprocal and Robertsonian translocations using array comparative genomic hybridization

Author(s) -

Francesco Fiorentino,

L. Spizzichino,

Sara Bono,

Anıl Biricik,

Georgia Kokkali,

Laura Rienzi,

Filippo Maria Ubaldi,

E. Iammarrone,

Adam Gordon,

K. Pantos

Publication year - 2011

Publication title -

human reproduction

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 2.446

H-Index - 226

eISSN - 1460-2350

pISSN - 0268-1161

DOI - 10.1093/humrep/der082

Subject(s) - comparative genomic hybridization , aneuploidy , biology , blastomere , embryo , chromosomal translocation , preimplantation genetic diagnosis , fluorescence in situ hybridization , chromosome , embryo transfer , ploidy , genetics , andrology , medicine , gene , embryogenesis

Fluorescence in situ hybridization (FISH) is the most widely used method for detecting unbalanced chromosome rearrangements in preimplantation embryos but it is known to have several technical limitations. We describe the clinical application of a molecular-based assay, array comparative genomic hybridization (array-CGH), to simultaneously screen for unbalanced translocation derivatives and aneuploidy of all 24 chromosomes.

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