Meiotic segregation of Robertsonian translocations ascertained in cleavage-stage embryos--implications for preimplantation genetic diagnosis | Zendy

Susan Bint | Zendy; Caroline Mackie Ogilvie | Zendy; Frances Flinter | Zendy; Yakoub Khalaf | Zendy; Paul N. Scriven | Zendy

Open Access

Meiotic segregation of Robertsonian translocations ascertained in cleavage-stage embryos--implications for preimplantation genetic diagnosis

Author(s) -

Susan Bint,

Caroline Mackie Ogilvie,

Frances Flinter,

Yakoub Khalaf,

Paul N. Scriven

Publication year - 2011

Publication title -

human reproduction

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 2.446

H-Index - 226

eISSN - 1460-2350

pISSN - 0268-1161

DOI - 10.1093/humrep/der080

Subject(s) - preimplantation genetic diagnosis , chromosomal translocation , robertsonian translocation , meiosis , biology , embryo , fluorescence in situ hybridization , genetics , andrology , karyotype , medicine , gene , chromosome

The aim of this study was to ascertain the prevalence of meiotic segregation products in embryos from carriers of 13/14 and 14/21 Robertsonian translocations and to estimate the predictive value of testing single cells using the fluorescence in situ hybridization (FISH) technique, to provide more information for decision-making about PGD.

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