Ovarian surface epitheliectomy in the non-human primate: continued cyclic ovarian function and limited epithelial replacement | Zendy

Jay W. Wright | Zendy; Tanja Pejović | Zendy; Leigh Jurevic | Zendy; Cecily V. Bishop | Zendy; Theodore R. Hobbs | Zendy; Richard L. Stouffer | Zendy

Open Access

Ovarian surface epitheliectomy in the non-human primate: continued cyclic ovarian function and limited epithelial replacement

Author(s) -

Jay W. Wright,

Tanja Pejović,

Leigh Jurevic,

Cecily V. Bishop,

Theodore R. Hobbs,

Richard L. Stouffer

Publication year - 2011

Publication title -

human reproduction

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 2.446

H-Index - 226

eISSN - 1460-2350

pISSN - 0268-1161

DOI - 10.1093/humrep/der061

Subject(s) - ovary , infertility , ovarian cancer , ovarian tissue , biology , macaque , rhesus macaque , epithelium , andrology , physiology , medicine , cancer , gynecology , oncology , endocrinology , immunology , pregnancy , neuroscience , genetics

The fifth leading cause of cancer deaths among women is ovarian cancer (OC), which originates primarily in the ovarian surface epithelium (OSE) that surrounds the ovary. Permanent removal of the OSE could provide a novel strategy to substantially reduce OC risk, while retaining the benefits of ovarian function, including gameto- and steroidogenesis. It must be determined whether ovarian surface epitheliectomy (OSEx) carries deleterious side effects, including loss of menstrual cyclicity, infertility or scarring (e.g. adhesions), prior to any clinical application of this strategy. To achieve this, we selected the non-human primate, rhesus macaque, for long-term (12 month) studies on the effects of OSEx.

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