Expression of CXCL12 and CXCR4 in human endometrium; effects of CXCL12 on MMP production by human endometrial cells | Zendy

Susan Laird | Zendy; R. Widdowson | Zendy; M. El-Sheikhi | Zendy; A.J. Hall | Zendy; Tin Chiu Li | Zendy

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Expression of CXCL12 and CXCR4 in human endometrium; effects of CXCL12 on MMP production by human endometrial cells

Author(s) -

Susan Laird,

R. Widdowson,

M. El-Sheikhi,

A.J. Hall,

Tin Chiu Li

Publication year - 2011

Publication title -

human reproduction

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 2.446

H-Index - 226

eISSN - 1460-2350

pISSN - 0268-1161

DOI - 10.1093/humrep/der043

Subject(s) - stromal cell , endometrium , cxcr4 , andrology , biology , immunostaining , immunohistochemistry , stroma , endometrial biopsy , matrix metalloproteinase , menstrual cycle , epithelium , chemokine , receptor , endocrinology , medicine , cancer research , immunology , biochemistry , genetics , hormone

Although several studies have suggested that CXCL12 and its receptor, CXCR4, may play a role in embryo implantation, there are limited reports of expression of CXCR4 and CXCL12 in human endometrium. The aim of this study was to investigate CXCL12 and CXCR4 expression in human endometrium and to see if CXCL12 could affect matrix metalloproteinase (MMP) production by endometrial stromal and epithelial cells.

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