Nuclear factor-kappa-B-inhibitor alpha (NFKBIA) is a developmental marker of NF- B/p65 activation during in vitro oocyte maturation and early embryogenesis | Zendy

Mariateresa Paciolla | Zendy; Raffaele Boni | Zendy; Francesca Fusco | Zendy; Alessandra Pescatore | Zendy; Loredana Poeta | Zendy; M. V. Ursini | Zendy; Maria Brigida Lioi | Zendy; Maria Giuseppina Miano | Zendy

Open Access

Nuclear factor-kappa-B-inhibitor alpha (NFKBIA) is a developmental marker of NF- B/p65 activation during in vitro oocyte maturation and early embryogenesis

Author(s) -

Mariateresa Paciolla,

Raffaele Boni,

Francesca Fusco,

Alessandra Pescatore,

Loredana Poeta,

M. V. Ursini,

Maria Brigida Lioi,

Maria Giuseppina Miano

Publication year - 2011

Publication title -

human reproduction

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 2.446

H-Index - 226

eISSN - 1460-2350

pISSN - 0268-1161

DOI - 10.1093/humrep/der040

Subject(s) - oocyte , biology , transcription factor , microbiology and biotechnology , iκbα , embryo , nfkb1 , nf κb , oocyte activation , signal transduction , genetics , gene

The oocyte-to-embryo transition (OET) requires a co-ordinated transcriptional programme acting through evolutionarily conserved events, and transcription factors (TFs) are known to control these processes. Here, we focus on nuclear factor (NF)-κB, a TF involved in several cellular processes, studying NFκB-inhibitor (NFKBIA) mRNA and its protein product, IκBα, during OET. NFKBIA and IκBα are part of a regulatory loop, as IκBα is the major down-regulator of NF-κB activation while NFKBIA transcription is activated by NF-κB.

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