Defective deacetylation of histone 4 K12 in human oocytes is associated with advanced maternal age and chromosome misalignment | Zendy

I. M. van den Berg | Zendy; C. Eleveld | Zendy; M. van der Hoeven | Zendy; Erwin Birnie | Zendy; Eric A.P. Steegers | Zendy; R. J. H. Galjaard | Zendy; Joop S.E. Laven | Zendy; J. Hikke van Doorninck | Zendy

Open Access

Defective deacetylation of histone 4 K12 in human oocytes is associated with advanced maternal age and chromosome misalignment

Author(s) -

I. M. van den Berg,

C. Eleveld,

M. van der Hoeven,

Erwin Birnie,

Eric A.P. Steegers,

R. J. H. Galjaard,

Joop S.E. Laven,

J. Hikke van Doorninck

Publication year - 2011

Publication title -

human reproduction

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 2.446

H-Index - 226

eISSN - 1460-2350

pISSN - 0268-1161

DOI - 10.1093/humrep/der030

Subject(s) - acetylation , chromosome , histone , andrology , genetics , biology , medicine , microbiology and biotechnology , gene

Chromosome segregation errors during human oocyte meiosis are associated with low fertility in humans and the incidence of these errors increases with advancing maternal age. Studies of mitosis and meiosis suggest that defective remodeling of chromatin plays a causative role in aneuploidy. We analyzed the histone deacetylation pattern during the final stages of human oocyte maturation to investigate whether defective epigenetic regulation of chromatin remodeling in human oocytes is related to maternal age and leads to segregation errors.

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