Gonadotrophin-induced paracrine regulation of human oocyte maturation by BDNF and GDNF secreted by granulosa cells | Zendy

Pan Zhao | Zendy; Jie Qiao | Zendy; Shuo Huang | Zendy; Ying Zhang | Zendy; Shujing Liu | Zendy; L.-y. Yan | Zendy; Aaron J.W. Hsueh | Zendy; Enkui Duan | Zendy

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Gonadotrophin-induced paracrine regulation of human oocyte maturation by BDNF and GDNF secreted by granulosa cells

Author(s) -

Pan Zhao,

Jie Qiao,

Shuo Huang,

Ying Zhang,

Shujing Liu,

L.-y. Yan,

Aaron J.W. Hsueh,

Enkui Duan

Publication year - 2011

Publication title -

human reproduction

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 2.446

H-Index - 226

eISSN - 1460-2350

pISSN - 0268-1161

DOI - 10.1093/humrep/deq390

Subject(s) - glial cell line derived neurotrophic factor , paracrine signalling , oocyte , neurotrophic factors , endocrinology , medicine , biology , autocrine signalling , andrology , granulosa cell , ovary , ovarian follicle , microbiology and biotechnology , receptor , embryo

In mammalian ovaries, diverse paracrine factors have been identified to mediate or modulate LH-induced changes during ovulation. Due to the difficulty in obtaining non-stimulated granulosa cells during IVF, little is known about the LH-induced paracrine factors in the human ovary. Based on earlier studies using murine ovarian cells showing the paracrine roles of brain-derived neurotrophic factor (BDNF) and glial cell line-derived neurotrophic factor (GDNF) in promoting oocyte maturation, we investigated the expression of these ligands in human granulosa cells and their regulation of human oocyte development.

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