Differential actions of glycodelin-A on Th-1 and Th-2 cells: a paracrine mechanism that could produce the Th-2 dominant environment during pregnancy | Zendy

CheukLun Lee | Zendy; Philip C.N. Chiu | Zendy; Kevin K.W. Lam | Zendy; Siu-On Siu | Zendy; Ivan K. Chu | Zendy; Riitta Koistinen | Zendy; Hannu Koistinen | Zendy; Markku Seppälä | Zendy; Ckf Lee | Zendy; William S.B. Yeung | Zendy

Open Access

Differential actions of glycodelin-A on Th-1 and Th-2 cells: a paracrine mechanism that could produce the Th-2 dominant environment during pregnancy

Author(s) -

CheukLun Lee,

Philip C.N. Chiu,

Kevin K.W. Lam,

Siu-On Siu,

Ivan K. Chu,

Riitta Koistinen,

Hannu Koistinen,

Markku Seppälä,

Ckf Lee,

William S.B. Yeung

Publication year - 2011

Publication title -

human reproduction

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 2.446

H-Index - 226

eISSN - 1460-2350

pISSN - 0268-1161

DOI - 10.1093/humrep/deq381

Subject(s) - decidua , biology , flow cytometry , paracrine signalling , cytokine , fas ligand , microbiology and biotechnology , programmed cell death , immunology , apoptosis , placenta , receptor , fetus , pregnancy , biochemistry , genetics

The maternal-fetal interface has a unique immunological response towards the implanting placenta. It is generally accepted that a T-helper type-2 (Th-2) cytokine prevailing environment is important in pregnancy. The proportion of Th-2 cells in the peripheral blood and decidua is significantly higher in pregnant women in the first trimester than in non-pregnant women. Glycodelin-A (GdA) is a major endocrine-regulated decidual glycoprotein thought to be related to fetomaternal defence. Yet the relationship between its immunoregulatory activities and the shift towards Th-2 cytokine profile during pregnancy is unclear.

The content you want is available to Zendy users.

Already have an account? Click here to sign in.

Having issues? You can contact us here

Accelerating Research