Meiotic activity in orthotopic xenografts derived from human postpubertal testicular tissue | Zendy

Dorien Van Saen | Zendy; Ellen Goossens | Zendy; C. Bourgain | Zendy; A Ferster | Zendy; Herman Tournaye | Zendy

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Meiotic activity in orthotopic xenografts derived from human postpubertal testicular tissue

Author(s) -

Dorien Van Saen,

Ellen Goossens,

C. Bourgain,

A Ferster,

Herman Tournaye

Publication year - 2010

Publication title -

human reproduction

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 2.446

H-Index - 226

eISSN - 1460-2350

pISSN - 0268-1161

DOI - 10.1093/humrep/deq321

Subject(s) - transplantation , andrology , germ cell , biology , spermatocyte , stem cell , cryopreservation , spermatogenesis , testicle , meiosis , embryo , medicine , endocrinology , microbiology and biotechnology , genetics , gene

Grafting of frozen-thawed testicular tissue has been suggested as a novel fertility preservation method for patients undergoing gonadotoxic treatments. However, this technique still needs further optimization before any clinical application. So far, grafting of human testicular tissue has only been performed to the back skin of nude mice and has shown spermatogonial stem-cell survival and occasionally differentiation up to primary spermatocytes. In this study, orthotopic grafting to mouse testes was evaluated as an alternative, and the effect of freezing and the donor's age was studied.

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