DNA integrity, growth pattern, spindle formation, chromosomal constitution and imprinting patterns of mouse oocytes from vitrified pre-antral follicles | Zendy

Tom Trapphoff | Zendy; Nady El Hajj | Zendy; Ulrich Zechner | Zendy; Thomas Haaf | Zendy; Ursula Eichenlaub-Ritter | Zendy

Open Access

DNA integrity, growth pattern, spindle formation, chromosomal constitution and imprinting patterns of mouse oocytes from vitrified pre-antral follicles

Author(s) -

Tom Trapphoff,

Nady El Hajj,

Ulrich Zechner,

Thomas Haaf,

Ursula Eichenlaub-Ritter

Publication year - 2010

Publication title -

human reproduction

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 2.446

H-Index - 226

eISSN - 1460-2350

pISSN - 0268-1161

DOI - 10.1093/humrep/deq278

Subject(s) - biology , genomic imprinting , oocyte , andrology , dna methylation , imprinting (psychology) , in vitro maturation , folliculogenesis , antral follicle , ovarian follicle , blastocyst , genetics , microbiology and biotechnology , cryopreservation , embryogenesis , embryo , ovary , medicine , gene expression , gene

Cryopreservation of follicles for culture and oocyte growth and maturation in vitro provides an option to increase the number of fertilizable oocytes and restore fertility in cases where transplantation of ovarian tissue poses a risk for malignant cell contamination. Vitrification for cryopreservation is fast and avoids ice crystal formation. However, the influences of exposure to high concentrations of cryoprotectants on follicle development, oocyte growth and maturation, and particularly, on the DNA integrity and methylation imprinting has not been studied systematically.

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