Growth/differentiation factor-15 is an abundant cytokine in human seminal plasma | Zendy

Karel Souček | Zendy; Eva Slabáková | Zendy; Petra Ovesná | Zendy; Alice Malenovská | Zendy; Alois Kozubı́k | Zendy; Aleš Hampl | Zendy

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Growth/differentiation factor-15 is an abundant cytokine in human seminal plasma

Author(s) -

Karel Souček,

Eva Slabáková,

Petra Ovesná,

Alice Malenovská,

Alois Kozubı́k,

Aleš Hampl

Publication year - 2010

Publication title -

human reproduction

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 2.446

H-Index - 226

eISSN - 1460-2350

pISSN - 0268-1161

DOI - 10.1093/humrep/deq264

Subject(s) - cytokine , biology , semen , immune system , growth factor , endocrinology , macrophage , medicine , immunology , andrology , receptor , anatomy , in vitro , biochemistry

Transforming growth factor-β cytokines have various biological effects in female reproductive tissue, including modulation of inflammatory response and induction of immune tolerance to seminal antigens in the reproductive tract. However, no studies have analyzed the presence of growth/differentiation factor-15 (GDF-15/macrophage inhibitory cytokine-1) in seminal fluid or demonstrated the quantity and form of GDF-15, its possible role or the relationship between its concentration and semen quality.

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