Polymorphisms of endocrine gland-derived vascular endothelial growth factor gene and its receptor genes are associated with recurrent pregnancy loss | Zendy

Mei-Tsz Su | Zendy; ShengHsiang Lin | Zendy; I.-W. Lee | Zendy; YiChen Chen | Zendy; C.-C. Hsu | Zendy; Hsien-An Pan | Zendy; PaoLin Kuo | Zendy

Open Access

Polymorphisms of endocrine gland-derived vascular endothelial growth factor gene and its receptor genes are associated with recurrent pregnancy loss

Author(s) -

Mei-Tsz Su,

ShengHsiang Lin,

I.-W. Lee,

YiChen Chen,

C.-C. Hsu,

Hsien-An Pan,

PaoLin Kuo

Publication year - 2010

Publication title -

human reproduction

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 2.446

H-Index - 226

eISSN - 1460-2350

pISSN - 0268-1161

DOI - 10.1093/humrep/deq256

Subject(s) - endocrinology , vascular endothelial growth factor , medicine , biology , receptor , placenta , endocrine system , kinase insert domain receptor , pregnancy , vascular endothelial growth factor a , cancer research , hormone , fetus , vegf receptors , genetics

Endocrine gland-derived vascular endothelial growth factor (EG-VEGF) and its receptor genes [prokineticin receptor 1 (PKR1) and prokineticin receptor 2 (PKR2)] have been identified in the last decade and their expression is restricted to the steroidogenic glands (ovary, testis, adrenal gland and placenta). Their expression patterns also suggest a close relationship to early pregnancy. However, little information is available regarding the role of EG-VEGF and its receptors (PKR1 and PKR2) in recurrent pregnancy loss (RPL). This study was conducted to investigate the association between polymorphisms of EG-VEGF and its receptor genes (PKR1 and PKR2) and idiopathic RPL.

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