Human oocytes express ATP-sensitive K+ channels | Zendy

Quan Du | Zendy; Aleksandar Jovanović | Zendy; Andrey Sukhodub | Zendy; Evelyn Barratt | Zendy; Emily Drew | Zendy; Katherine Whalley | Zendy; V. Kay | Zendy; Martin McLaughlin | Zendy; Evelyn E. Telfer | Zendy; Christopher L. R. Barratt | Zendy

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Human oocytes express ATP-sensitive K+ channels

Author(s) -

Quan Du,

Aleksandar Jovanović,

Andrey Sukhodub,

Evelyn Barratt,

Emily Drew,

Katherine Whalley,

V. Kay,

Martin McLaughlin,

Evelyn E. Telfer,

Christopher L. R. Barratt

Publication year - 2010

Publication title -

human reproduction

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 2.446

H-Index - 226

eISSN - 1460-2350

pISSN - 0268-1161

DOI - 10.1093/humrep/deq245

Subject(s) - kir6.2 , intracellular , microbiology and biotechnology , potassium channel , oocyte , chemistry , biology , protein subunit , biochemistry , biophysics , gene , embryo

ATP-sensitive K(+) (K(ATP)) channels link intracellular metabolism with membrane excitability and play crucial roles in cellular physiology and protection. The K(ATP) channel protein complex is composed of pore forming, Kir6.x (Kir6.1 or Kir6.2) and regulatory, SURx (SUR2A, SUR2B or SUR1), subunits that associate in different combinations. The objective of this study was to determine whether mammalian oocytes (human, bovine, porcine) express K(ATP) channels.

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