Open AccessEffect of dienogest administration on angiogenesis and hemodynamics in a rat endometrial autograft model
Author(s) -
Hirokazu Katayama,
Tohru Katayama,
Kazuhiko Uematsu,
Mie Hiratsuka,
Masaki Kiyomura,
Yutaka Shimizu,
Atsuro Sugita,
Ito M
Publication year - 2010
Publication title -
human reproduction
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 2.446
H-Index - 226
eISSN - 1460-2350
pISSN - 0268-1161
DOI - 10.1093/humrep/deq241
Subject(s) - angiogenesis , dienogest , endometrium , microvessel , in vivo , neovascularization , microcirculation , transplantation , endometriosis , medicine , endocrinology , andrology , urology , biology , microbiology and biotechnology
We aimed to establish an endometrial autograft model in rats that would allow for repetitive in vivo analyses of angiogenesis. Dienogest (DNG) is an orally active progestin used for the treatment of endometriosis. We investigated whether DNG would affect angiogenesis of the ectopic endometrium in our model.