The effect of DNA methylation inhibitor 5-Aza-2′-deoxycytidine on human endometrial stromal cells | Zendy

Philip C. Logan | Zendy; Anna P. Ponnampalam | Zendy; Fahimeh Rahnama | Zendy; Peter E. Lobie | Zendy; Murray D. Mitchell | Zendy

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The effect of DNA methylation inhibitor 5-Aza-2′-deoxycytidine on human endometrial stromal cells

Author(s) -

Philip C. Logan,

Anna P. Ponnampalam,

Fahimeh Rahnama,

Peter E. Lobie,

Murray D. Mitchell

Publication year - 2010

Publication title -

human reproduction

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 2.446

H-Index - 226

eISSN - 1460-2350

pISSN - 0268-1161

DOI - 10.1093/humrep/deq238

Subject(s) - decidualization , dna methylation , stromal cell , biology , epigenetics , endometrium , decidua , placentation , methylation , microbiology and biotechnology , andrology , cancer research , endocrinology , gene expression , placenta , gene , genetics , medicine , fetus , pregnancy

Decidualization, the differentiation of endometrial stromal cells is a crucial step for successful implantation of an embryo, development of the placenta and completion of pregnancy to term. Epigenetic mechanisms are thought to be strongly involved in the regulation of processes controlling implantation, placentation, organ formation and foetal growth. Recent studies suggest that decreased DNA methylation facilitates a receptive endometrium. Hence, the aim of this project was to compare the transcriptional profile changes induced by the inhibitor of DNA methylation, 5-Aza-2'-deoxycytidine (AZA) to the transcriptional changes that happen during decidualization.

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