Appearance of an oocyte activation-related substance during spermatogenesis in mice and humans | Zendy

Chizuru Ito | Zendy; Kenji Yamatoya | Zendy; Keiichi Yoshida | Zendy; Koichi Kyono | Zendy; Rutao Yao | Zendy; T Noda | Zendy; Kiyotaka Toshimori | Zendy

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Appearance of an oocyte activation-related substance during spermatogenesis in mice and humans

Author(s) -

Chizuru Ito,

Kenji Yamatoya,

Keiichi Yoshida,

Koichi Kyono,

Rutao Yao,

T Noda,

Kiyotaka Toshimori

Publication year - 2010

Publication title -

human reproduction

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 2.446

H-Index - 226

eISSN - 1460-2350

pISSN - 0268-1161

DOI - 10.1093/humrep/deq216

Subject(s) - acrosome , oocyte , microbiology and biotechnology , sperm , spermatogenesis , spermiogenesis , acrosome reaction , biology , chemistry , endocrinology , genetics , embryo

Recently we reported that an oocyte activation ability in human and mouse sperm is associated with head flatness or the presence of perinuclear theca (PT) substance, MN13, which is an oocyte activation-related protein localized on the post-acrosomal sheath (PAS). As such, we hypothesize that the appearance of oocyte activation ability is stage-specifically regulated and depends on the formation of the acrosome or PAS/PT in spermatids.

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