Genetic variation within the hypothalamus-pituitary-ovarian axis in women with recurrent miscarriage | Zendy

Courtney W. Hanna | Zendy; Karla L. Bretherick | Zendy; Chi-Chao Liu | Zendy; Mary D. Stephenson | Zendy; Wendy P. Robinson | Zendy

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Genetic variation within the hypothalamus-pituitary-ovarian axis in women with recurrent miscarriage

Author(s) -

Courtney W. Hanna,

Karla L. Bretherick,

Chi-Chao Liu,

Mary D. Stephenson,

Wendy P. Robinson

Publication year - 2010

Publication title -

human reproduction

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 2.446

H-Index - 226

eISSN - 1460-2350

pISSN - 0268-1161

DOI - 10.1093/humrep/deq211

Subject(s) - single nucleotide polymorphism , recurrent miscarriage , candidate gene , endocrinology , biology , medicine , miscarriage , genotype , allele , genetics , pregnancy , gene

Recurrent miscarriage affects 1-2% of couples trying to conceive, and is idiopathic in nearly half. Female fertility is controlled by the hypothalamus-pituitary-ovarian (HPO) axis and we hypothesize that genetic polymorphisms affecting the function of genes involved in regulating the HPO axis will be associated with recurrent miscarriage.

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