Open AccessDiagnostic accuracy: theoretical models for preimplantation genetic testing of a single nucleus using the fluorescence in situ hybridization technique
Author(s) -
Paul N. Scriven,
Patrick M. Bossuyt
Publication year - 2010
Publication title -
human reproduction
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 2.446
H-Index - 226
eISSN - 1460-2350
pISSN - 0268-1161
DOI - 10.1093/humrep/deq196
Subject(s) - aneuploidy , fluorescence in situ hybridization , chromosomal translocation , chromosome , biology , preimplantation genetic diagnosis , ploidy , karyotype , genetics , embryo , gene
The aim of this study was to develop and use theoretical models to investigate the accuracy of the fluorescence in situ hybridization (FISH) technique in testing a single nucleus from a preimplantation embryo without the complicating effect of mosaicism.
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